Expression of SGSM2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SGSM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SGSM2
Gene description	Small G protein signaling modulator 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA021641 , HPA024553
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and head and neck cancer (favourable).
Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021641	HPA024553

GENE INFORMATION
Gene name	SGSM2 (HGNC Symbol)
Synonyms	KIAA0397, RUTBC1
Description	Small G protein signaling modulator 2 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2337498 - 2381058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141258 (version 83.38)
Entrez gene	9905
UniProt	O43147 (UniProt - Evidence at protein level)
neXtProt	NX_O43147
Antibodypedia	SGSM2 antibodies

PROTEIN BROWSER

SGSM2-001	SGSM2-002	SGSM2-003	SGSM2-010	SGSM2-011	SGSM2-012	SGSM2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGSM2-001 ENSP00000415107 ENST00000426855	O43147 [Direct mapping] Small G protein signaling modulator 2 B9A6J3 [Target identity:100%; Query identity:100%] RUN and TBC1 domain-containing protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0017137 [Rab GTPase binding] GO:0034499 [late endosome to Golgi transport] GO:0043547 [positive regulation of GTPase activity] Show all	1006 aa 113.3 kDa	No	0
SGSM2-002 ENSP00000268989 ENST00000268989	O43147 [Direct mapping] Small G protein signaling modulator 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0017137 [Rab GTPase binding] GO:0034499 [late endosome to Golgi transport] GO:0043547 [positive regulation of GTPase activity] Show all	1051 aa 118.3 kDa	No	0
SGSM2-003 ENSP00000459126 ENST00000574563	O43147 [Direct mapping] Small G protein signaling modulator 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0017137 [Rab GTPase binding] GO:0034499 [late endosome to Golgi transport] GO:0043547 [positive regulation of GTPase activity] Show all	987 aa 110.9 kDa	No	0
SGSM2-010 ENSP00000460205 ENST00000570431	I3L361 [Direct mapping] Small G protein-signaling modulator 2 Show all	Predicted intracellular proteins Show all		95 aa 10.5 kDa	No	0
SGSM2-011 ENSP00000476637 ENST00000574650	V9GYD2 [Direct mapping] Small G protein-signaling modulator 2 Show all	Predicted intracellular proteins Show all		70 aa 7.5 kDa	No	0
SGSM2-012 ENSP00000464593 ENST00000573851	J3QSA2 [Direct mapping] Small G protein-signaling modulator 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		114 aa 13.2 kDa	No	0
SGSM2-013 ENSP00000461820 ENST00000572925	I3NI18 [Direct mapping] Small G protein-signaling modulator 2 Show all	Predicted intracellular proteins Show all		36 aa 4.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.