Expression of SCRN2 in cancer - Summary - The Human Protein Atlas

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SCRN2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SCRN2
Gene description	Secernin 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA022934 , HPA023434
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and urothelial cancer (favourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022934	HPA023434

GENE INFORMATION
Gene name	SCRN2
Synonyms
Description	Secernin 2 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47837692 - 47841333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141295 (version 83.38)
Entrez gene	90507
UniProt	Q96FV2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FV2
Antibodypedia	SCRN2 antibodies

PROTEIN BROWSER

SCRN2-001	SCRN2-002	SCRN2-006	SCRN2-011	SCRN2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCRN2-001 ENSP00000290216 ENST00000290216	Q96FV2 [Direct mapping] Secernin-2 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005623 [cell] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0008150 [biological_process] GO:0016805 [dipeptidase activity] GO:0070062 [extracellular exosome] Show all	425 aa 46.6 kDa	No	0
SCRN2-002 ENSP00000383935 ENST00000407215	Q96FV2 [Direct mapping] Secernin-2 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005623 [cell] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0008150 [biological_process] GO:0016805 [dipeptidase activity] GO:0070062 [extracellular exosome] Show all	378 aa 41.3 kDa	No	0
SCRN2-006 ENSP00000463411 ENST00000584123	J3QL71 [Direct mapping] Secernin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] Show all	433 aa 47.5 kDa	No	0
SCRN2-011 ENSP00000463809 ENST00000584567	J3QQM9 [Direct mapping] Secernin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006887 [exocytosis] Show all	269 aa 29.6 kDa	No	0
SCRN2-013 ENSP00000464093 ENST00000578323	J3QR84 [Direct mapping] Secernin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] Show all	180 aa 19.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.