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SPACA3

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GENERAL INFORMATION

Gene name

 SPACA3

Gene description

 Sperm acrosome associated 3

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SPACA3 (HGNC Symbol)

Synonyms

 ALLP17, CT54, LYC3, LYZL3, SLLP1

Description

 Sperm acrosome associated 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 32970376 - 32997877

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141316 (version 83.38)

Entrez gene

 124912

UniProt

 Q8IXA5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IXA5

Antibodypedia

 SPACA3 antibodies

PROTEIN BROWSER
SPACA3-001
SPACA3-003
SPACA3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPACA3-001
ENSP00000269053
ENST00000269053
Q8IXA5 [Direct mapping]
Sperm acrosome membrane-associated protein 3 Sperm acrosome membrane-associated protein 3, membrane form Sperm acrosome membrane-associated protein 3, processed form
A0A080YUZ7 [Target identity:100%; Query identity:100%]
Lysozyme C; Sperm acrosome associated 3, isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001669 [acrosomal vesicle]
GO:0002080 [acrosomal membrane]
GO:0003796 [lysozyme activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005764 [lysosome]
GO:0009253 [peptidoglycan catabolic process]
GO:0009566 [fertilization]
GO:0009615 [response to virus]
GO:0016021 [integral component of membrane]
GO:0016998 [cell wall macromolecule catabolic process]
GO:0030141 [secretory granule]
GO:0035036 [sperm-egg recognition]
GO:0042117 [monocyte activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 215 aa
23.4 kDa 		No 1
SPACA3-003
ENSP00000378134
ENST00000394638
E9PF91 [Direct mapping]
Sperm acrosome membrane-associated protein 3
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Predicted intracellular proteins
Show all
GO:0003796 [lysozyme activity]
GO:0008152 [metabolic process]
GO:0009566 [fertilization]
Show all
 112 aa
12.6 kDa 		No 0
SPACA3-005
ENSP00000463386
ENST00000580599
Q8IXA5 [Direct mapping]
Sperm acrosome membrane-associated protein 3 Sperm acrosome membrane-associated protein 3, membrane form Sperm acrosome membrane-associated protein 3, processed form
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002080 [acrosomal membrane]
GO:0003796 [lysozyme activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005764 [lysosome]
GO:0009253 [peptidoglycan catabolic process]
GO:0009566 [fertilization]
GO:0009615 [response to virus]
GO:0016021 [integral component of membrane]
GO:0016998 [cell wall macromolecule catabolic process]
GO:0030141 [secretory granule]
GO:0042117 [monocyte activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 146 aa
16.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.