Expression of ABCA8 in cancer - Summary - The Human Protein Atlas

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ABCA8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCA8
Gene description	ATP-binding cassette, sub-family A (ABC1), member 8
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (ASC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA044914
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044914

GENE INFORMATION
Gene name	ABCA8 (HGNC Symbol)
Synonyms	KIAA0822
Description	ATP-binding cassette, sub-family A (ABC1), member 8 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The encoded protein may regulate lipid metabolism and be involved in the formation and maintenance of myelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	68867292 - 68955392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141338 (version 83.38)
Entrez gene	10351
UniProt	O94911 (UniProt - Evidence at protein level)
neXtProt	NX_O94911
Antibodypedia	ABCA8 antibodies

PROTEIN BROWSER

ABCA8-001	ABCA8-003	ABCA8-009	ABCA8-201	ABCA8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCA8-001 ENSP00000269080 ENST00000269080	O94911 [Direct mapping] ATP-binding cassette sub-family A member 8 A0A024R8L6 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family A (ABC1), member 8, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	1581 aa 179.2 kDa	No	>9
ABCA8-003 ENSP00000467271 ENST00000586539	O94911 [Direct mapping] ATP-binding cassette sub-family A member 8 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	1621 aa 183.7 kDa	No	>9
ABCA8-009 ENSP00000466126 ENST00000585531	K7ELK9 [Direct mapping] ATP-binding cassette sub-family A member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005743 [mitochondrial inner membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	115 aa 13.4 kDa	No	1
ABCA8-201 ENSP00000402814 ENST00000430352	A0A0A0MSU4 [Direct mapping] ATP-binding cassette sub-family A member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	1616 aa 183.1 kDa	No	>9
ABCA8-202 ENSP00000481467 ENST00000615593	Q49AI9 [Direct mapping] ABCA8 protein; ATP-binding cassette sub-family A member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005743 [mitochondrial inner membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	156 aa 17.9 kDa	No	1

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The Human Protein Atlas

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