Expression of SS18 in cancer - Summary - The Human Protein Atlas

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SS18

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SS18
Gene description	Synovial sarcoma translocation, chromosome 18
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA055741 , HPA059539
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055741	HPA059539

GENE INFORMATION
Gene name	SS18 (HGNC Symbol)
Synonyms	SSXT, SYT
Description	Synovial sarcoma translocation, chromosome 18 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	26016253 - 26091217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141380 (version 83.38)
Entrez gene	6760
UniProt	Q15532 (UniProt - Evidence at protein level)
neXtProt	NX_Q15532
Antibodypedia	SS18 antibodies

PROTEIN BROWSER

SS18-001	SS18-002	SS18-003	SS18-022	SS18-023	SS18-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SS18-001 ENSP00000269137 ENST00000269137	Q15532 [Direct mapping] Protein SSXT Q4VAX0 [Target identity:100%; Query identity:100%] Synovial sarcoma translocation, chromosome 18; Synovial sarcoma translocation, chromosome 18, isoform CRA_a; cDNA FLJ57021, highly similar to SSXT protein; cDNA, FLJ79201, highly similar to SSXT protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	387 aa 42.2 kDa	No	0
SS18-002 ENSP00000438066 ENST00000542420	B4DLD3 [Direct mapping] Protein SSXT; cDNA FLJ58120, highly similar to SSXT protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		395 aa 43.5 kDa	No	0
SS18-003 ENSP00000414516 ENST00000415083	Q15532 [Direct mapping] Protein SSXT A0A024RC40 [Target identity:100%; Query identity:100%] Synovial sarcoma translocation, chromosome 18, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0000902 [cell morphogenesis] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005881 [cytoplasmic microtubule] GO:0006351 [transcription, DNA-templated] GO:0007010 [cytoskeleton organization] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0035556 [intracellular signal transduction] GO:0042493 [response to drug] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048013 [ephrin receptor signaling pathway] GO:0071564 [npBAF complex] GO:0097150 [neuronal stem cell population maintenance] Show all	418 aa 45.9 kDa	No	0
SS18-022 ENSP00000463586 ENST00000581021	J3QLJ7 [Direct mapping] Protein SSXT Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.7 kDa	No	0
SS18-023 ENSP00000463943 ENST00000584083	J3QQX5 [Direct mapping] Protein SSXT Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14 kDa	No	0
SS18-024 ENSP00000462766 ENST00000579061	J3KT22 [Direct mapping] Protein SSXT Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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