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TAF4B

GENERAL INFORMATION

Gene name

 TAF4B

Gene description

 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Daudi)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028937
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028937

GENE INFORMATION

Gene name

 TAF4B (HGNC Symbol)

Synonyms

 TAF2C2, TAFII105

Description

 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (HGNC Symbol)

Entrez gene summary

 TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 26225936 - 26391685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141384 (version 83.38)

Entrez gene

 6875

UniProt

 Q92750 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92750

Antibodypedia

 TAF4B antibodies

PROTEIN BROWSER
TAF4B-001
TAF4B-002
TAF4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF4B-001
ENSP00000462980
ENST00000578121
J3KTH2 [Direct mapping]
HCG38478, isoform CRA_a; Transcription initiation factor TFIID subunit 4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:2000648 [positive regulation of stem cell proliferation]
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 867 aa
91.7 kDa 		No 0
TAF4B-002
ENSP00000269142
ENST00000269142
Q92750 [Direct mapping]
Transcription initiation factor TFIID subunit 4B
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0046982 [protein heterodimerization activity]
GO:0048477 [oogenesis]
GO:0051059 [NF-kappaB binding]
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 862 aa
91.1 kDa 		No 0
TAF4B-201
ENSP00000383314
ENST00000400466
A0A0A0MSA8 [Direct mapping]
Transcription initiation factor TFIID subunit 4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
Show all
 865 aa
91.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.