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Most malignancies displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Several cases of malignant gliomas and renal cancer were weakly stained or negative.
GENE INFORMATION
Gene name
AFG3L2 (HGNC Symbol)
Synonyms
SCA28, SPAX5
Description
AFG3-like AAA ATPase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008]