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IMPA2

GENERAL INFORMATION

Gene name

 IMPA2

Gene description

 Inositol(myo)-1(or 4)-monophosphatase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, SiHa)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in squamous epithelia, kidney and pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA029561
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA029561

GENE INFORMATION

Gene name

 IMPA2

Synonyms

Description

 Inositol(myo)-1(or 4)-monophosphatase 2 (HGNC Symbol)

Entrez gene summary

 This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 11981025 - 12030883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141401 (version 83.38)

Entrez gene

 3613

UniProt

 O14732 (UniProt - Evidence at protein level)

neXtProt

 NX_O14732

Antibodypedia

 IMPA2 antibodies

PROTEIN BROWSER
IMPA2-001
IMPA2-003
IMPA2-005
IMPA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IMPA2-001
ENSP00000269159
ENST00000269159
O14732 [Direct mapping]
Inositol monophosphatase 2
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0006021 [inositol biosynthetic process]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0007165 [signal transduction]
GO:0008934 [inositol monophosphate 1-phosphatase activity]
GO:0042803 [protein homodimerization activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0052832 [inositol monophosphate 3-phosphatase activity]
GO:0052833 [inositol monophosphate 4-phosphatase activity]
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 288 aa
31.3 kDa 		No 0
IMPA2-003
ENSP00000464767
ENST00000588927
K7EII9 [Direct mapping]
Inositol monophosphatase 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046854 [phosphatidylinositol phosphorylation]
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 99 aa
10.5 kDa 		No 0
IMPA2-005
ENSP00000465416
ENST00000589238
K7EII9 [Direct mapping]
Inositol monophosphatase 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046854 [phosphatidylinositol phosphorylation]
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 99 aa
10.5 kDa 		No 0
IMPA2-201
ENSP00000486461
ENST00000625802
Q6PIP6 [Direct mapping]
IMPA2 protein; Inositol monophosphatase 2; Inositol monophosphatase 2 variant 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046854 [phosphatidylinositol phosphorylation]
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 85 aa
9.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.