Expression of C18orf21 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

C18orf21

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C18orf21
Gene description	Chromosome 18 open reading frame 21
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA065505 , HPA067322
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065505	HPA067322

GENE INFORMATION
Gene name	C18orf21 (HGNC Symbol)
Synonyms	HsT3108, PNAS-124, PNAS-131
Description	Chromosome 18 open reading frame 21 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	35972083 - 35979286
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141428 (version 83.38)
Entrez gene	83608
UniProt	Q32NC0 (UniProt - Evidence at protein level)
neXtProt	NX_Q32NC0
Antibodypedia	C18orf21 antibodies

PROTEIN BROWSER

C18orf21-001	C18orf21-002	C18orf21-004	C18orf21-005	C18orf21-201	C18orf21-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C18orf21-001 ENSP00000465517 ENST00000592875	Q32NC0 [Direct mapping] UPF0711 protein C18orf21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		220 aa 24.8 kDa	No	0
C18orf21-002 ENSP00000329492 ENST00000333234	Q32NC0 [Direct mapping] UPF0711 protein C18orf21 W4VSQ2 [Target identity:100%; Query identity:100%] Chromosome 18 open reading frame 21, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.5 kDa	No	0
C18orf21-004 ENSP00000269194 ENST00000269194	L7N2F3 [Direct mapping] UPF0711 protein C18orf21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.2 kDa	No	0
C18orf21-005 ENSP00000466400 ENST00000587873	K7EM84 [Direct mapping] UPF0711 protein C18orf21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.6 kDa	No	0
C18orf21-201 ENSP00000480486 ENST00000610527	Q32NC0 [Direct mapping] UPF0711 protein C18orf21 W4VSQ2 [Target identity:100%; Query identity:100%] Chromosome 18 open reading frame 21, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.5 kDa	No	0
C18orf21-202 ENSP00000483334 ENST00000618334	A0A087X0E7 [Direct mapping] UPF0711 protein C18orf21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.