Expression of ASXL3 in cancer - Summary - The Human Protein Atlas

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ASXL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASXL3
Gene description	Additional sex combs like transcriptional regulator 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (AF22, HEK93, RPMI-8226, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (ovary)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA039539 , HPA040034
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039539	HPA040034

GENE INFORMATION
Gene name	ASXL3 (HGNC Symbol)
Synonyms	KIAA1713
Description	Additional sex combs like transcriptional regulator 3 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	33578615 - 33751192
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000141431 (version 83.38)
Entrez gene	80816
UniProt	Q9C0F0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9C0F0
Antibodypedia	ASXL3 antibodies

PROTEIN BROWSER

ASXL3-002	ASXL3-004	ASXL3-008	ASXL3-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASXL3-002 ENSP00000269197 ENST00000269197	Q9C0F0 [Direct mapping] Putative Polycomb group protein ASXL3 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	2248 aa 241.9 kDa	No	0
ASXL3-004 ENSP00000468024 ENST00000590189	K7EQY1 [Direct mapping] Putative Polycomb group protein ASXL3 Show all	Predicted intracellular proteins Show all	GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	179 aa 19.6 kDa	No	0
ASXL3-008 ENSP00000466244 ENST00000586327	K7ELW2 [Direct mapping] Putative Polycomb group protein ASXL3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	148 aa 15.8 kDa	No	0
ASXL3-015 ENSP00000465634 ENST00000586596	K7EKI3 [Direct mapping] Putative Polycomb group protein ASXL3 Show all	Predicted intracellular proteins Show all	GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	175 aa 18.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.