Fields »
ABOUT
HELP
BLOG
ADCYAP1

GENERAL INFORMATION

Gene name

 ADCYAP1

Gene description

 Adenylate cyclase activating polypeptide 1 (pituitary)

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, cerebral cortex, gallbladder)
GTEx:Tissue enhanced (hypothalamus)
FANTOM5:Tissue enhanced (brain, cerebellum)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, cerebral cortex, gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum)

GENE INFORMATION

Gene name

 ADCYAP1 (HGNC Symbol)

Synonyms

 PACAP

Description

 Adenylate cyclase activating polypeptide 1 (pituitary) (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 904943 - 912172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141433 (version 83.38)

Entrez gene

 116

UniProt

 P18509 (UniProt - Evidence at protein level)

neXtProt

 NX_P18509

Antibodypedia

 ADCYAP1 antibodies

PROTEIN BROWSER
ADCYAP1-002
ADCYAP1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCYAP1-002
ENSP00000411658
ENST00000450565
P18509 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide PACAP-related peptide Pituitary adenylate cyclase-activating polypeptide 27 Pituitary adenylate cyclase-activating polypeptide 38
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016521 [pituitary adenylate cyclase activating polypeptide activity]
GO:0019933 [cAMP-mediated signaling]
GO:0031175 [neuron projection development]
GO:0032880 [regulation of protein localization]
GO:0043547 [positive regulation of GTPase activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051428 [peptide hormone receptor binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
Show all
 176 aa
18.8 kDa 		Yes 0
ADCYAP1-003
ENSP00000462647
ENST00000579794
P18509 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide PACAP-related peptide Pituitary adenylate cyclase-activating polypeptide 27 Pituitary adenylate cyclase-activating polypeptide 38
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001541 [ovarian follicle development]
GO:0001662 [behavioral fear response]
GO:0001821 [histamine secretion]
GO:0002865 [negative regulation of acute inflammatory response to antigenic stimulus]
GO:0002878 [negative regulation of acute inflammatory response to non-antigenic stimulus]
GO:0005057 [receptor signaling protein activity]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010976 [positive regulation of neuron projection development]
GO:0016521 [pituitary adenylate cyclase activating polypeptide activity]
GO:0019233 [sensory perception of pain]
GO:0019933 [cAMP-mediated signaling]
GO:0021983 [pituitary gland development]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031175 [neuron projection development]
GO:0031858 [pituitary adenylate cyclase-activating polypeptide receptor binding]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032880 [regulation of protein localization]
GO:0034260 [negative regulation of GTPase activity]
GO:0042594 [response to starvation]
GO:0043195 [terminal bouton]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043547 [positive regulation of GTPase activity]
GO:0045471 [response to ethanol]
GO:0045786 [negative regulation of cell cycle]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046034 [ATP metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051428 [peptide hormone receptor binding]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060078 [regulation of postsynaptic membrane potential]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070445 [regulation of oligodendrocyte progenitor proliferation]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0090274 [positive regulation of somatostatin secretion]
Show all
 176 aa
18.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.