Expression of MEP1B in cancer - Summary - The Human Protein Atlas

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MEP1B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MEP1B
Gene description	Meprin A, beta
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (pancreatic cancer, stomach cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in brush border membrane in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA029119
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029119

GENE INFORMATION
Gene name	MEP1B
Synonyms
Description	Meprin A, beta (HGNC Symbol)
Entrez gene summary	Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	32185069 - 32220404
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141434 (version 83.38)
Entrez gene	4225
UniProt	Q16820 (UniProt - Evidence at protein level)
neXtProt	NX_Q16820
Antibodypedia	MEP1B antibodies

PROTEIN BROWSER

MEP1B-001	MEP1B-002	MEP1B-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEP1B-001 ENSP00000269202 ENST00000269202	Q16820 [Direct mapping] Meprin A subunit beta Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0007586 [digestion] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:1901998 [toxin transport] Show all	701 aa 79.6 kDa	Yes	1
MEP1B-002 ENSP00000463280 ENST00000581447	J3QKX5 [Direct mapping] Metalloendopeptidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	700 aa 79.4 kDa	Yes	1
MEP1B-004 ENSP00000462038 ENST00000581184	J3KRK1 [Direct mapping] Meprin A subunit beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016020 [membrane] Show all	114 aa 13 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.