Cell atlas - PELP1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PELP1

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PELP1
Gene description	Proline, glutamate and leucine rich protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA053966 , HPA056028
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (validated), Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053966	CACO-2	Nucleoplasm
	HPA053966	MCF7	Nucleus
	HPA053966	MCF7	Nucleoli
	HPA053966	U-2 OS	Nucleus
	HPA053966	U-2 OS	Nucleoli
	HPA056028	CACO-2	Nucleus
	HPA056028	CACO-2	Nucleoli
	HPA056028	MCF7	Nucleus
	HPA056028	U-2 OS	Nucleus
	HPA056028	U-2 OS	Nucleoli

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000018921 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053966	NIH 3T3	Nucleoplasm
	HPA056028	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	PELP1 (HGNC Symbol)
Synonyms	MNAR
Description	Proline, glutamate and leucine rich protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4669774 - 4704337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141456 (version 83.38)
Entrez gene	27043
UniProt	Q8IZL8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZL8
Antibodypedia	PELP1 antibodies

PROTEIN BROWSER

PELP1-001	PELP1-006	PELP1-008	PELP1-011	PELP1-015	PELP1-201	PELP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PELP1-001 ENSP00000460300 ENST00000572293	C9JFV4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0071391 [cellular response to estrogen stimulus] Show all	1180 aa 124.9 kDa	No	0
PELP1-006 ENSP00000458985 ENST00000575101	I3L1P4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 15 kDa	No	0
PELP1-008 ENSP00000461419 ENST00000570387	I3L4P1 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071391 [cellular response to estrogen stimulus] Show all	100 aa 11 kDa	No	0
PELP1-011 ENSP00000460959 ENST00000570571	I3L445 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	301 aa 32.1 kDa	No	0
PELP1-015 ENSP00000461625 ENST00000574876	Q8IZL8 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0035327 [transcriptionally active chromatin] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071339 [MLL1 complex] GO:0071391 [cellular response to estrogen stimulus] Show all	1130 aa 119.7 kDa	No	0
PELP1-201 ENSP00000301396 ENST00000301396	C9JFV4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0071391 [cellular response to estrogen stimulus] Show all	1180 aa 124.9 kDa	No	0
PELP1-202 ENSP00000416231 ENST00000436683	E7EV54 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] Show all	906 aa 96.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.