Expression of SLC14A1 in cancer - Summary - The Human Protein Atlas

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SLC14A1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC14A1
Gene description	Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
Protein class	Blood group antigen proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, prostate cancer, urothelial cancer)
HPA (cell line):	Cell line enriched (RT4)
HPA (normal tissue):	Group enriched (prostate, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in erythrocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA059570
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, prostate cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059570

GENE INFORMATION
Gene name	SLC14A1 (HGNC Symbol)
Synonyms	HsT1341, JK, RACH1, RACH2
Description	Solute carrier family 14 (urea transporter), member 1 (Kidd blood group) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]
Chromosome	18
Cytoband	q12.3
Chromosome location (bp)	45724127 - 45752520
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141469 (version 83.38)
Entrez gene	6563
UniProt	Q13336 (UniProt - Evidence at protein level)
neXtProt	NX_Q13336
Antibodypedia	SLC14A1 antibodies

PROTEIN BROWSER

SLC14A1-002	SLC14A1-003	SLC14A1-004	SLC14A1-005	SLC14A1-006	SLC14A1-009	SLC14A1-010	SLC14A1-011	SLC14A1-012	SLC14A1-013	SLC14A1-014	SLC14A1-015	SLC14A1-016	SLC14A1-019	SLC14A1-022	SLC14A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC14A1-002 ENSP00000318546 ENST00000321925	Q13336 [Direct mapping] Urea transporter 1 G0W2N5 [Target identity:100%; Query identity:100%] Solute carrier family 14; Solute carrier family 14 (Urea transporter), member 1 (Kidd blood group), isoform CRA_a Show all	Blood group antigen proteins Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	389 aa 42.5 kDa	No	8
SLC14A1-003 ENSP00000442180 ENST00000502059	B3KXJ3 [Direct mapping] Urea transporter 1; cDNA FLJ45544 fis, clone BRTHA2033683, highly similar to Urea transporter, erythrocyte Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	281 aa 30.6 kDa	No	7
SLC14A1-004 ENSP00000385320 ENST00000402943	B4DFJ8 [Direct mapping] Urea transporter 1; cDNA FLJ59493, highly similar to Urea transporter, erythrocyte Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	284 aa 30.9 kDa	No	7
SLC14A1-005 ENSP00000441998 ENST00000535474	F5GWS2 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	257 aa 28.1 kDa	No	5
SLC14A1-006 ENSP00000412309 ENST00000415427	Q13336 [Direct mapping] Urea transporter 1 Show all	Blood group antigen proteins Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	445 aa 48.3 kDa	No	8
SLC14A1-009 ENSP00000390637 ENST00000436407	Q13336 [Direct mapping] Urea transporter 1 Show all	Blood group antigen proteins Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005372 [water transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006833 [water transport] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	445 aa 48.3 kDa	No	8
SLC14A1-010 ENSP00000470476 ENST00000586142	Q13336 [Direct mapping] Urea transporter 1 G0W2N5 [Target identity:100%; Query identity:100%] Solute carrier family 14; Solute carrier family 14 (Urea transporter), member 1 (Kidd blood group), isoform CRA_a Show all	Blood group antigen proteins Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	389 aa 42.5 kDa	No	8
SLC14A1-011 ENSP00000465044 ENST00000589700	E9NSU1 [Direct mapping] Truncated urea transporter; Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	302 aa 33.6 kDa	No	4
SLC14A1-012 ENSP00000465029 ENST00000587601	K7EJ54 [Direct mapping] Urea transporter 1 Show all	Predicted intracellular proteins Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	28 aa 3 kDa	No	0
SLC14A1-013 ENSP00000465702 ENST00000586951	K7EKN6 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	102 aa 11.3 kDa	No	1
SLC14A1-014 ENSP00000470055 ENST00000586056	M0QYS8 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	136 aa 14.9 kDa	No	2
SLC14A1-015 ENSP00000466093 ENST00000589891	K7ELI3 [Direct mapping] Urea transporter 1 Show all	Predicted intracellular proteins Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	129 aa 14.1 kDa	No	0
SLC14A1-016 ENSP00000468763 ENST00000590246	K7ESL3 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	116 aa 12.8 kDa	No	3
SLC14A1-019 ENSP00000465150 ENST00000590377	K7EJF6 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	173 aa 19.1 kDa	No	2
SLC14A1-022 ENSP00000466273 ENST00000589322	M0QX00 [Direct mapping] Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	169 aa 18.2 kDa	No	4
SLC14A1-201 ENSP00000479595 ENST00000619403	E9NSU1 [Direct mapping] Truncated urea transporter; Urea transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0071918 [urea transmembrane transport] Show all	302 aa 33.6 kDa	No	5

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