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ARRB2

GENERAL INFORMATION

Gene namei

 ARRB2

Gene descriptioni

 Arrestin, beta 2

Protein classi

 Predicted intracellular proteins

Predicted localizationi

 Intracellular

Number of transcriptsi

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidencei

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability scorei

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARYi
Prognostic marker in prostate cancer (unfavourable) and cervical cancer (favourable).
Prostate cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Pending cancer tissue analysis

STAINING SUMMARYi

 

GENE INFORMATIONi

Gene name

 ARRB2 (HGNC Symbol)

Synonyms

 ARR2, BARR2, DKFZp686L0365

Description

 Arrestin, beta 2 (HGNC Symbol)

Entrez gene summary

 Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4710489 - 4721499

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141480 (version 83.38)

Entrez gene

 409

UniProt

 P32121 (UniProt - Evidence at protein level)

neXtProt

 NX_P32121

Antibodypedia

 ARRB2 antibodies

PROTEIN BROWSERi
ARRB2-001
ARRB2-002
ARRB2-003
ARRB2-004
ARRB2-006
ARRB2-007
ARRB2-008
ARRB2-009
ARRB2-020

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARRB2-001
ENSP00000341895
ENST00000346341
P32121 [Direct mapping]
Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002031 [G-protein coupled receptor internalization]
GO:0002032 [desensitization of G-protein coupled receptor protein signaling pathway by arrestin]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031701 [angiotensin receptor binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032947 [protein complex scaffold]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045953 [negative regulation of natural killer cell mediated cytotoxicity]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0060326 [cell chemotaxis]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 406 aa
45.6 kDa 		No 0
ARRB2-002
ENSP00000269260
ENST00000269260
P32121 [Direct mapping]
Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002031 [G-protein coupled receptor internalization]
GO:0002032 [desensitization of G-protein coupled receptor protein signaling pathway by arrestin]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031701 [angiotensin receptor binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032947 [protein complex scaffold]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045953 [negative regulation of natural killer cell mediated cytotoxicity]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0060326 [cell chemotaxis]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 409 aa
46.1 kDa 		No 0
ARRB2-003
ENSP00000465296
ENST00000572457
Q68DZ5 [Direct mapping]
Beta-arrestin-2; Putative uncharacterized protein DKFZp686L0365; cDNA FLJ58316, highly similar to Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 217 aa
24.4 kDa 		No 0
ARRB2-004
ENSP00000466344
ENST00000574954
Q68DZ5 [Direct mapping]
Beta-arrestin-2; Putative uncharacterized protein DKFZp686L0365; cDNA FLJ58316, highly similar to Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 217 aa
24.4 kDa 		No 0
ARRB2-006
ENSP00000403701
ENST00000412477
P32121 [Direct mapping]
Beta-arrestin-2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002031 [G-protein coupled receptor internalization]
GO:0002032 [desensitization of G-protein coupled receptor protein signaling pathway by arrestin]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006897 [endocytosis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007420 [brain development]
GO:0007596 [blood coagulation]
GO:0007628 [adult walking behavior]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016323 [basolateral plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031691 [alpha-1A adrenergic receptor binding]
GO:0031692 [alpha-1B adrenergic receptor binding]
GO:0031701 [angiotensin receptor binding]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031762 [follicle-stimulating hormone receptor binding]
GO:0031826 [type 2A serotonin receptor binding]
GO:0031859 [platelet activating factor receptor binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032226 [positive regulation of synaptic transmission, dopaminergic]
GO:0032403 [protein complex binding]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032947 [protein complex scaffold]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0042699 [follicle-stimulating hormone signaling pathway]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043197 [dendritic spine]
GO:0043422 [protein kinase B binding]
GO:0045211 [postsynaptic membrane]
GO:0045953 [negative regulation of natural killer cell mediated cytotoxicity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060326 [cell chemotaxis]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071889 [14-3-3 protein binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 430 aa
48 kDa 		No 0
ARRB2-007
ENSP00000466857
ENST00000575877
K7ENA6 [Direct mapping]
Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 330 aa
36.6 kDa 		No 0
ARRB2-008
ENSP00000460607
ENST00000571206
Q68DZ5 [Direct mapping]
Beta-arrestin-2; Putative uncharacterized protein DKFZp686L0365; cDNA FLJ58316, highly similar to Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 217 aa
24.4 kDa 		No 0
ARRB2-009
ENSP00000370898
ENST00000381488
P32121 [Direct mapping]
Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002031 [G-protein coupled receptor internalization]
GO:0002032 [desensitization of G-protein coupled receptor protein signaling pathway by arrestin]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031701 [angiotensin receptor binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032947 [protein complex scaffold]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045953 [negative regulation of natural killer cell mediated cytotoxicity]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0060326 [cell chemotaxis]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 394 aa
44.4 kDa 		No 0
ARRB2-020
ENSP00000465877
ENST00000571428
K7EL17 [Direct mapping]
Beta-arrestin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 113 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.