Expression of TMC6 in cancer - Summary - The Human Protein Atlas

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TMC6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMC6
Gene description	Transmembrane channel-like 6
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (K-562)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051430
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable) and urothelial cancer (favourable).
Stomach cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051430

GENE INFORMATION
Gene name	TMC6 (HGNC Symbol)
Synonyms	EVER1, EVIN1, LAK-4P
Description	Transmembrane channel-like 6 (HGNC Symbol)
Entrez gene summary	Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78110458 - 78132407
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141524 (version 83.38)
Entrez gene	11322
UniProt	Q7Z403 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z403
Antibodypedia	TMC6 antibodies

PROTEIN BROWSER

TMC6-001	TMC6-002	TMC6-003	TMC6-007	TMC6-009	TMC6-010	TMC6-015	TMC6-016	TMC6-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC6-001 ENSP00000376260 ENST00000392467	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 A0A024R8V2 [Target identity:100%; Query identity:100%] Transmembrane channel-like protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	805 aa 90 kDa	No	9
TMC6-002 ENSP00000313408 ENST00000322914	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 A0A024R8V2 [Target identity:100%; Query identity:100%] Transmembrane channel-like protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	805 aa 90 kDa	No	9
TMC6-003 ENSP00000465359 ENST00000589553	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	298 aa 32.5 kDa	No	5
TMC6-007 ENSP00000465261 ENST00000590602	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 A0A024R8V2 [Target identity:100%; Query identity:100%] Transmembrane channel-like protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	805 aa 90 kDa	No	9
TMC6-009 ENSP00000464853 ENST00000591436	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	384 aa 43.3 kDa	No	5
TMC6-010 ENSP00000467016 ENST00000592594	K7ENM6 [Direct mapping] Transmembrane channel-like protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 16.1 kDa	No	0
TMC6-015 ENSP00000468255 ENST00000589271	K7ERH0 [Direct mapping] Transmembrane channel-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	286 aa 31.7 kDa	No	1
TMC6-016 ENSP00000466885 ENST00000592063	K7ENC4 [Direct mapping] Transmembrane channel-like protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.3 kDa	No	0
TMC6-026 ENSP00000306405 ENST00000306591	Q7Z403 [Direct mapping] Transmembrane channel-like protein 6 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	454 aa 50.3 kDa	No	2

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