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CSNK1D

GENERAL INFORMATION

Gene name

 CSNK1D

Gene description

 Casein kinase 1, delta

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB015410
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CSNK1D (HGNC Symbol)

Synonyms

 CKID, CKIdelta, HCKID

Description

 Casein kinase 1, delta (HGNC Symbol)

Entrez gene summary

 This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 82239023 - 82273731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141551 (version 83.38)

Entrez gene

 1453

UniProt

 P48730 (UniProt - Evidence at protein level)

neXtProt

 NX_P48730

Antibodypedia

 CSNK1D antibodies

PROTEIN BROWSER
CSNK1D-001
CSNK1D-002
CSNK1D-006
CSNK1D-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSNK1D-001
ENSP00000324464
ENST00000314028
P48730 [Direct mapping]
Casein kinase I isoform delta
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001948 [glycoprotein binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034067 [protein localization to Golgi apparatus]
GO:0035058 [nonmotile primary cilium assembly]
GO:0042277 [peptide binding]
GO:0042752 [regulation of circadian rhythm]
GO:0043005 [neuron projection]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0051219 [phosphoprotein binding]
GO:0051225 [spindle assembly]
GO:0061024 [membrane organization]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 415 aa
47.3 kDa 		No 0
CSNK1D-002
ENSP00000376146
ENST00000392334
P48730 [Direct mapping]
Casein kinase I isoform delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034067 [protein localization to Golgi apparatus]
GO:0035058 [nonmotile primary cilium assembly]
GO:0042752 [regulation of circadian rhythm]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0051225 [spindle assembly]
GO:0061024 [membrane organization]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 409 aa
46.8 kDa 		No 0
CSNK1D-006
ENSP00000381531
ENST00000398519
H7BYT1 [Direct mapping]
Casein kinase I isoform delta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 427 aa
49.1 kDa 		No 0
CSNK1D-015
ENSP00000463757
ENST00000580446
J3QQI9 [Direct mapping]
Casein kinase I isoform delta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 187 aa
21.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.