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FOXK2

GENERAL INFORMATION

Gene name

 FOXK2

Gene description

 Forkhead box K2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027523
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027523

GENE INFORMATION

Gene name

 FOXK2 (HGNC Symbol)

Synonyms

 ILF, ILF1

Description

 Forkhead box K2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 82519713 - 82644662

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141568 (version 83.38)

Entrez gene

 3607

UniProt

 Q01167 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01167

Antibodypedia

 FOXK2 antibodies

PROTEIN BROWSER
FOXK2-001
FOXK2-004
FOXK2-005
FOXK2-011
FOXK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXK2-001
ENSP00000335677
ENST00000335255
Q01167 [Direct mapping]
Forkhead box protein K2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 660 aa
69.1 kDa 		No 0
FOXK2-004
ENSP00000433167
ENST00000531030
E9PM37 [Direct mapping]
Forkhead box protein K2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 172 aa
19.1 kDa 		No 0
FOXK2-005
ENSP00000432663
ENST00000526383
E9PPI7 [Direct mapping]
Forkhead box protein K2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 254 aa
27.8 kDa 		No 0
FOXK2-011
ENSP00000461540
ENST00000575578
I3L4U8 [Direct mapping]
Forkhead box protein K2
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
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 129 aa
13.5 kDa 		No 0
FOXK2-201
ENSP00000481132
ENST00000622867
A0A087WXM0 [Direct mapping]
Forkhead box protein K2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 610 aa
64.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.