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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CBX4
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CBX4

Gene description

Chromobox homolog 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA008228
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008228

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and nuclear staining was observed in most cancer tissues. Several melanomas and breast cancers were strongly stained.

GENE INFORMATION

Gene name

CBX4 (HGNC Symbol)

Synonyms

hPC2, NBP16, PC2

Description

Chromobox homolog 4 (HGNC Symbol)

Entrez gene summary

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

79833156 - 79839429

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141582 (version 83.38)

Entrez gene

8535

UniProt

O00257 (UniProt - Evidence at protein level)

neXtProt

NX_O00257

Antibodypedia

CBX4 antibodies

PROTEIN BROWSER

CBX4-001
CBX4-002
CBX4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBX4-001
ENSP00000269397
ENST00000269397
O00257 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0016568 [chromatin modification]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0031519 [PcG protein complex]
GO:0032183 [SUMO binding]
GO:0035064 [methylated histone binding]
GO:0035102 [PRC1 complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043687 [post-translational protein modification]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051219 [phosphoprotein binding]
Show all
560 aa
61.4 kDa
No 0
CBX4-002
ENSP00000415348
ENST00000448310
F8WCW6 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
60 aa
7.2 kDa
No 0
CBX4-004
ENSP00000461198
ENST00000495122
I3L4F1 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
90 aa
10.2 kDa
No 0

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The Human Protein Atlas project is funded
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