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TNFRSF11A

GENERAL INFORMATION

Gene name

 TNFRSF11A

Gene description

 Tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Protein class

 CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (duodenum)
GTEx:Mixed
FANTOM5:Tissue enhanced (salivary gland, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA027728 , CAB010391
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, small intestine)

GENE INFORMATION

Gene name

 TNFRSF11A (HGNC Symbol)

Synonyms

 CD265, FEO, LOH18CR1, PDB2, RANK

Description

 Tumor necrosis factor receptor superfamily, member 11a, NFKB activator (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

Chromosome

 18

Cytoband

 q21.33

Chromosome location (bp)

 62325287 - 62391292

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141655 (version 83.38)

Entrez gene

 8792

UniProt

 Q9Y6Q6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6Q6

Antibodypedia

 TNFRSF11A antibodies

PROTEIN BROWSER
TNFRSF11A-001
TNFRSF11A-002
TNFRSF11A-201
TNFRSF11A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF11A-001
ENSP00000465500
ENST00000586569
Q9Y6Q6 [Direct mapping]
Tumor necrosis factor receptor superfamily member 11A
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0001503 [ossification]
GO:0002250 [adaptive immune response]
GO:0002548 [monocyte chemotaxis]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008284 [positive regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0019955 [cytokine binding]
GO:0030316 [osteoclast differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034612 [response to tumor necrosis factor]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046872 [metal ion binding]
GO:0048535 [lymph node development]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060086 [circadian temperature homeostasis]
GO:0060749 [mammary gland alveolus development]
GO:0070555 [response to interleukin-1]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:0097190 [apoptotic signaling pathway]
Show all
 616 aa
66 kDa 		Yes 1
TNFRSF11A-002
ENSP00000269485
ENST00000269485
Q9Y6Q6 [Direct mapping]
Tumor necrosis factor receptor superfamily member 11A
Show all
CD markers
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002250 [adaptive immune response]
GO:0002548 [monocyte chemotaxis]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0019955 [cytokine binding]
GO:0030316 [osteoclast differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034612 [response to tumor necrosis factor]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060086 [circadian temperature homeostasis]
GO:0070555 [response to interleukin-1]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:0097190 [apoptotic signaling pathway]
Show all
 299 aa
32.3 kDa 		Yes 0
TNFRSF11A-201
ENSP00000479567
ENST00000616710
Q9Y6Q6 [Direct mapping]
Tumor necrosis factor receptor superfamily member 11A
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002250 [adaptive immune response]
GO:0002548 [monocyte chemotaxis]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0019955 [cytokine binding]
GO:0030316 [osteoclast differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034612 [response to tumor necrosis factor]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060086 [circadian temperature homeostasis]
GO:0070555 [response to interleukin-1]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:0097190 [apoptotic signaling pathway]
Show all
 263 aa
29 kDa 		Yes 1
TNFRSF11A-202
ENSP00000482466
ENST00000617039
Q9Y6Q6 [Direct mapping]
Tumor necrosis factor receptor superfamily member 11A
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0002250 [adaptive immune response]
GO:0002548 [monocyte chemotaxis]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0019955 [cytokine binding]
GO:0030316 [osteoclast differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034612 [response to tumor necrosis factor]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060086 [circadian temperature homeostasis]
GO:0070555 [response to interleukin-1]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:0097190 [apoptotic signaling pathway]
Show all
 337 aa
36.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.