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NT5C3B

GENERAL INFORMATION

Gene name

 NT5C3B

Gene description

 5'-nucleotidase, cytosolic IIIB

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA030786 , HPA057095
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030786
HPA057095

GENE INFORMATION

Gene name

 NT5C3B (HGNC Symbol)

Synonyms

 MGC20781, NT5C3L

Description

 5'-nucleotidase, cytosolic IIIB (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41825181 - 41836263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141698 (version 83.38)

Entrez gene

 115024

UniProt

 Q969T7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969T7

Antibodypedia

 NT5C3B antibodies

PROTEIN BROWSER
NT5C3B-008
NT5C3B-009
NT5C3B-013
NT5C3B-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NT5C3B-008
ENSP00000389948
ENST00000435506
Q969T7 [Direct mapping]
7-methylguanosine phosphate-specific 5'-nucleotidase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008253 [5'-nucleotidase activity]
GO:0009117 [nucleotide metabolic process]
GO:0010467 [gene expression]
GO:0016311 [dephosphorylation]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
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 300 aa
34.4 kDa 		No 0
NT5C3B-009
ENSP00000397742
ENST00000415460
C9J758 [Direct mapping]
7-methylguanosine phosphate-specific 5'-nucleotidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0008253 [5'-nucleotidase activity]
GO:0016311 [dephosphorylation]
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 227 aa
25.8 kDa 		No 0
NT5C3B-013
ENSP00000475710
ENST00000486304
U3KQB1 [Direct mapping]
7-methylguanosine phosphate-specific 5'-nucleotidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0008253 [5'-nucleotidase activity]
GO:0016311 [dephosphorylation]
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 105 aa
12 kDa 		No 0
NT5C3B-017
ENSP00000429878
ENST00000521789
E5RH64 [Direct mapping]
7-methylguanosine phosphate-specific 5'-nucleotidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0008253 [5'-nucleotidase activity]
GO:0016311 [dephosphorylation]
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 200 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.