Expression of FAM134C in cancer - Summary - The Human Protein Atlas

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FAM134C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM134C
Gene description	Family with sequence similarity 134, member C
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA016492
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016492

GENE INFORMATION
Gene name	FAM134C (HGNC Symbol)
Synonyms	DKFZp686B1036, FLJ33806
Description	Family with sequence similarity 134, member C (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42579513 - 42610623
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141699 (version 83.38)
Entrez gene	162427
UniProt	Q86VR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VR2
Antibodypedia	FAM134C antibodies

PROTEIN BROWSER

FAM134C-001	FAM134C-002	FAM134C-005	FAM134C-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM134C-001 ENSP00000309432 ENST00000309428	Q86VR2 [Direct mapping] Protein FAM134C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] Show all	466 aa 51.4 kDa	No	3
FAM134C-002 ENSP00000467847 ENST00000585894	K7EQI9 [Direct mapping] Protein FAM134C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	369 aa 40.8 kDa	No	2
FAM134C-005 ENSP00000467332 ENST00000588423	K7EPD0 [Direct mapping] Protein FAM134C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 12.4 kDa	No	1
FAM134C-006 ENSP00000465016 ENST00000591547	K7EJ42 [Direct mapping] Protein FAM134C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	120 aa 13.9 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.