Expression of ERBB2 in cancer - Summary - The Human Protein Atlas

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ERBB2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERBB2
Gene description	Erb-b2 receptor tyrosine kinase 2
Protein class	Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (SK-BR-3)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with cases of membrane positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 4 antibodies. HPA001383 , CAB000043 , CAB020416 , CAB062555
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001383	CAB000043	CAB020416	CAB062555

GENE INFORMATION
Gene name	ERBB2 (HGNC Symbol)
Synonyms	CD340, HER-2, HER2, NEU, NGL
Description	Erb-b2 receptor tyrosine kinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39687914 - 39730426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141736 (version 83.38)
Entrez gene	2064
UniProt	P04626 (UniProt - Evidence at protein level)
neXtProt	NX_P04626
Antibodypedia	ERBB2 antibodies

PROTEIN BROWSER

ERBB2-001	ERBB2-003	ERBB2-004	ERBB2-005	ERBB2-008	ERBB2-012	ERBB2-013	ERBB2-015	ERBB2-018	ERBB2-019	ERBB2-201	ERBB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERBB2-001 ENSP00000462438 ENST00000584601	P04626 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001042 [RNA polymerase I core binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010008 [endosome membrane] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0030307 [positive regulation of cell growth] GO:0032886 [regulation of microtubule-based process] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071363 [cellular response to growth factor stimulus] GO:0090314 [positive regulation of protein targeting to membrane] Show all	1225 aa 134.9 kDa	No	1
ERBB2-003 ENSP00000462808 ENST00000578199	F5H1T4 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	603 aa 66.5 kDa	No	0
ERBB2-004 ENSP00000404047 ENST00000445658	B4DTR1 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	979 aa 107.6 kDa	Yes	1
ERBB2-005 ENSP00000463714 ENST00000584450	J3QLU9 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0023014 [signal transduction by protein phosphorylation] Show all	1055 aa 117.1 kDa	Yes	1
ERBB2-008 ENSP00000269571 ENST00000269571	P04626 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 X5DNK3 [Target identity:100%; Query identity:100%] Receptor protein-tyrosine kinase Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001042 [RNA polymerase I core binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0007528 [neuromuscular junction development] GO:0008022 [protein C-terminus binding] GO:0008045 [motor neuron axon guidance] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010008 [endosome membrane] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0030307 [positive regulation of cell growth] GO:0031410 [cytoplasmic vesicle] GO:0032886 [regulation of microtubule-based process] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042552 [myelination] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043209 [myelin sheath] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0048709 [oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071363 [cellular response to growth factor stimulus] GO:0090314 [positive regulation of protein targeting to membrane] Show all	1255 aa 137.9 kDa	Yes	1
ERBB2-012 ENSP00000463719 ENST00000578709	J3QLV2 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.5 kDa	No	0
ERBB2-013 ENSP00000462270 ENST00000584099	J3KS21 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.6 kDa	No	0
ERBB2-015 ENSP00000464420 ENST00000578502	J3QRX1 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	166 aa 18.1 kDa	No	0
ERBB2-018 ENSP00000463002 ENST00000580074	J3KTI5 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	251 aa 27.7 kDa	No	1
ERBB2-019 ENSP00000464252 ENST00000582818	J3QRJ7 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	177 aa 19.4 kDa	No	1
ERBB2-201 ENSP00000385185 ENST00000406381	P04626 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001042 [RNA polymerase I core binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010008 [endosome membrane] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0030307 [positive regulation of cell growth] GO:0032886 [regulation of microtubule-based process] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071363 [cellular response to growth factor stimulus] GO:0090314 [positive regulation of protein targeting to membrane] Show all	1225 aa 134.9 kDa	No	1
ERBB2-202 ENSP00000446466 ENST00000541774	P04626 [Direct mapping] Receptor tyrosine-protein kinase erbB-2 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001042 [RNA polymerase I core binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010008 [endosome membrane] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0030307 [positive regulation of cell growth] GO:0032886 [regulation of microtubule-based process] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071363 [cellular response to growth factor stimulus] GO:0090314 [positive regulation of protein targeting to membrane] Show all	1240 aa 136.5 kDa	No	1

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