Expression of PNMT in cancer - Summary - The Human Protein Atlas

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PNMT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNMT
Gene description	Phenylethanolamine N-methyltransferase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Cell line enhanced (K-562, NB-4, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in adrenal medulla.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA043412 , HPA051005 , CAB017029
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043412	HPA051005	CAB017029

GENE INFORMATION
Gene name	PNMT (HGNC Symbol)
Synonyms	PENT
Description	Phenylethanolamine N-methyltransferase (HGNC Symbol)
Entrez gene summary	The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39667981 - 39670475
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141744 (version 83.38)
Entrez gene	5409
UniProt	P11086 (UniProt - Evidence at protein level)
neXtProt	NX_P11086
Antibodypedia	PNMT antibodies

PROTEIN BROWSER

PNMT-001	PNMT-002	PNMT-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMT-001 ENSP00000269582 ENST00000269582	P11086 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004603 [phenylethanolamine N-methyltransferase activity] GO:0005829 [cytosol] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042418 [epinephrine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	282 aa 30.9 kDa	No	0
PNMT-002 ENSP00000377791 ENST00000394246	A8MT87 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	184 aa 20.6 kDa	No	0
PNMT-003 ENSP00000464234 ENST00000581428	J3QRI3 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	137 aa 14.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.