Fields »
ABOUT
HELP
BLOG
FKBP10

GENERAL INFORMATION

Gene name

 FKBP10

Gene description

 FK506 binding protein 10, 65 kDa

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic fibroblast expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA051171 , HPA057021
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051171
HPA057021

GENE INFORMATION

Gene name

 FKBP10 (HGNC Symbol)

Synonyms

 FKBP6, FLJ20683, FLJ22041, FLJ23833, hFKBP65

Description

 FK506 binding protein 10, 65 kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41812680 - 41823217

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141756 (version 83.38)

Entrez gene

 60681

UniProt

 Q96AY3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96AY3

Antibodypedia

 FKBP10 antibodies

PROTEIN BROWSER
FKBP10-001
FKBP10-003
FKBP10-004
FKBP10-010
FKBP10-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP10-001
ENSP00000317232
ENST00000321562
Q96AY3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP10
A0A024R1W3 [Target identity:100%; Query identity:100%]
FK506 binding protein 10, 65 kDa, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 582 aa
64.2 kDa 		Yes 0
FKBP10-003
ENSP00000408232
ENST00000429461
C9JPC3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 81 aa
8.9 kDa 		No 0
FKBP10-004
ENSP00000416822
ENST00000455106
H0Y827 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005509 [calcium ion binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 386 aa
42.2 kDa 		No 0
FKBP10-010
ENSP00000468703
ENST00000585664
K7ESG6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 172 aa
19.2 kDa 		No 0
FKBP10-011
ENSP00000466097
ENST00000585922
K7ELI6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 171 aa
18.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.