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The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
O60885 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000794 [condensed nuclear chromosome] GO:0001833 [inner cell mass cell proliferation] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007059 [chromosome segregation] GO:0008024 [positive transcription elongation factor complex b] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016032 [viral process] GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043388 [positive regulation of DNA binding] GO:0043983 [histone H4-K12 acetylation] GO:0044154 [histone H3-K14 acetylation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050727 [regulation of inflammatory response] GO:0070577 [lysine-acetylated histone binding] GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain] GO:2000002 [negative regulation of DNA damage checkpoint]
O60885 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000794 [condensed nuclear chromosome] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016032 [viral process] GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050727 [regulation of inflammatory response] GO:0070577 [lysine-acetylated histone binding] GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain] GO:2000002 [negative regulation of DNA damage checkpoint]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000794 [condensed nuclear chromosome] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016032 [viral process] GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050727 [regulation of inflammatory response] GO:0070577 [lysine-acetylated histone binding] GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain] GO:2000002 [negative regulation of DNA damage checkpoint]
M0QZD9 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
M0R0H4 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
