Expression of PLPP2 in cancer - Summary

GENERAL INFORMATION
Gene name	PLPP2
Gene description	Phospholipid phosphatase 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549, CAPAN-2)
HPA (normal tissue):	Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in glandular cells, most abundant in gastrointestinal tract, salivary gland and gallbladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA055540
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and breast cancer (unfavourable).
Endometrial cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA055540

GENE INFORMATION
Gene name	PLPP2 (HGNC Symbol)
Synonyms	LPP2, PAP-2c, PPAP2C
Description	Phospholipid phosphatase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	281040 - 291504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141934 (version 83.38)
Entrez gene	8612
UniProt	O43688 (UniProt - Evidence at protein level)
neXtProt	NX_O43688
Antibodypedia	PLPP2 antibodies

PROTEIN BROWSER

PLPP2-001	PLPP2-002	PLPP2-003	PLPP2-004	PLPP2-005	PLPP2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPP2-001 ENSP00000388565 ENST00000434325	O43688 [Direct mapping] Lipid phosphate phosphohydrolase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0016020 [membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0042577 [lipid phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046839 [phospholipid dephosphorylation] Show all	288 aa 32.6 kDa	No	6
PLPP2-002 ENSP00000466545 ENST00000591572	K7EMK9 [Direct mapping] Lipid phosphate phosphohydrolase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008195 [phosphatidate phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] Show all	178 aa 19.8 kDa	Yes	2
PLPP2-003 ENSP00000269812 ENST00000269812	O43688 [Direct mapping] Lipid phosphate phosphohydrolase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0016020 [membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0042577 [lipid phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046839 [phospholipid dephosphorylation] Show all	232 aa 26.1 kDa	No	4
PLPP2-004 ENSP00000329697 ENST00000327790	O43688 [Direct mapping] Lipid phosphate phosphohydrolase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0016020 [membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0042577 [lipid phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046839 [phospholipid dephosphorylation] Show all	309 aa 34.4 kDa	No	6
PLPP2-005 ENSP00000466947 ENST00000586998	K7ENH4 [Direct mapping] Lipid phosphate phosphohydrolase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008195 [phosphatidate phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] Show all	136 aa 15.4 kDa	No	3
PLPP2-008 ENSP00000488312 ENST00000633125		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		208 aa 23.5 kDa	No	4