Expression of DPP9 in cancer - Summary - The Human Protein Atlas

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DPP9

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPP9
Gene description	Dipeptidyl-peptidase 9
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036059
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), stomach cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Stomach cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036059

GENE INFORMATION
Gene name	DPP9
Synonyms
Description	Dipeptidyl-peptidase 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4675224 - 4724673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142002 (version 83.38)
Entrez gene	91039
UniProt	Q86TI2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TI2
Antibodypedia	DPP9 antibodies

PROTEIN BROWSER

DPP9-001	DPP9-003	DPP9-006	DPP9-007	DPP9-008	DPP9-010	DPP9-011	DPP9-014	DPP9-016	DPP9-017	DPP9-020	DPP9-022	DPP9-025	DPP9-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPP9-001 ENSP00000262960 ENST00000262960	Q86TI2 [Direct mapping] Dipeptidyl peptidase 9 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0042802 [identical protein binding] Show all	892 aa 101.7 kDa	No	0
DPP9-003 ENSP00000472430 ENST00000597849	M0R2A8 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	518 aa 59.1 kDa	No	0
DPP9-006 ENSP00000472549 ENST00000600621	M0R2G6 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.9 kDa	No	0
DPP9-007 ENSP00000471629 ENST00000601130	M0R145 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.6 kDa	No	0
DPP9-008 ENSP00000473130 ENST00000602161	M0R3C4 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.9 kDa	No	0
DPP9-010 ENSP00000469020 ENST00000599248	M0QXA6 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.4 kDa	No	0
DPP9-011 ENSP00000469282 ENST00000593973	M0QXN4 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 1.9 kDa	No	0
DPP9-014 ENSP00000469187 ENST00000601720	M0QXI5 [Direct mapping] Dipeptidyl peptidase 9 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	220 aa 24.7 kDa	No	0
DPP9-016 ENSP00000471954 ENST00000595327	M0R1L4 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	141 aa 15.7 kDa	No	0
DPP9-017 ENSP00000471250 ENST00000598360	M0R0I1 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.4 kDa	No	0
DPP9-020 ENSP00000473175 ENST00000597726	M0R3E8 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	68 aa 7.6 kDa	No	0
DPP9-022 ENSP00000469152 ENST00000598041	M0QXG6 [Direct mapping] Dipeptidyl peptidase 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.7 kDa	No	0
DPP9-025 ENSP00000472224 ENST00000594671	Q86TI2 [Direct mapping] Dipeptidyl peptidase 9 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0042802 [identical protein binding] Show all	836 aa 95 kDa	No	0
DPP9-026 ENSP00000469603 ENST00000598800	Q86TI2 [Direct mapping] Dipeptidyl peptidase 9 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0042802 [identical protein binding] Show all	863 aa 98.3 kDa	No	0

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