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DMRTC2

GENERAL INFORMATION

Gene name

 DMRTC2

Gene description

 DMRT-like family C2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nucleolar expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA045016
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 DMRTC2

Synonyms

Description

 DMRT-like family C2 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 41844743 - 41852333

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142025 (version 83.38)

Entrez gene

 63946

UniProt

 Q8IXT2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IXT2

Antibodypedia

 DMRTC2 antibodies

PROTEIN BROWSER
DMRTC2-001
DMRTC2-003
DMRTC2-004
DMRTC2-006
DMRTC2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMRTC2-001
ENSP00000269945
ENST00000269945
Q8IXT2 [Direct mapping]
Doublesex- and mab-3-related transcription factor C2
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001741 [XY body]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007141 [male meiosis I]
GO:0007290 [spermatid nucleus elongation]
GO:0007548 [sex differentiation]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:1900111 [positive regulation of histone H3-K9 dimethylation]
GO:1900114 [positive regulation of histone H3-K9 trimethylation]
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 367 aa
39.1 kDa 		No 0
DMRTC2-003
ENSP00000469525
ENST00000596827
B4DX56 [Direct mapping]
Doublesex- and mab-3-related transcription factor C2; cDNA FLJ61444, highly similar to Doublesex- and mab-3-related transcription factor C2
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Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
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 418 aa
44.8 kDa 		No 0
DMRTC2-004
ENSP00000472488
ENST00000600017
M0R2D7 [Direct mapping]
Doublesex- and mab-3-related transcription factor C2
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Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
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 165 aa
18.2 kDa 		No 0
DMRTC2-006
ENSP00000472215
ENST00000596258
M0R1Z9 [Direct mapping]
Doublesex- and mab-3-related transcription factor C2
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Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
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 135 aa
15.3 kDa 		No 0
DMRTC2-007
ENSP00000470553
ENST00000596660
M0QZH7 [Direct mapping]
Doublesex- and mab-3-related transcription factor C2
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Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
Show all
 161 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.