Expression of ATHL1 in cancer - Summary - The Human Protein Atlas

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ATHL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATHL1
Gene description	ATH1, acid trehalase-like 1 (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039383
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039383

GENE INFORMATION
Gene name	ATHL1 (HGNC Symbol)
Synonyms	FLJ22635
Description	ATH1, acid trehalase-like 1 (yeast) (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	289135 - 296107
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142102 (version 83.38)
Entrez gene	80162
UniProt	Q32M88 (UniProt - Evidence at protein level)
neXtProt	NX_Q32M88
Antibodypedia	ATHL1 antibodies

PROTEIN BROWSER

ATHL1-001	ATHL1-002	ATHL1-004	ATHL1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATHL1-001 ENSP00000386297 ENST00000409655	B8ZZ60 [Direct mapping] Acid trehalase-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	489 aa 53.8 kDa	No	0
ATHL1-002 ENSP00000387099 ENST00000409479	E7EMA9 [Direct mapping] Acid trehalase-like protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	764 aa 83.4 kDa	No	0
ATHL1-004 ENSP00000387185 ENST00000409548	Q32M88 [Direct mapping] Acid trehalase-like protein 1 A0A024R1Z9 [Target identity:100%; Query identity:100%] ATH1, acid trehalase-like 1 (Yeast), isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004555 [alpha,alpha-trehalase activity] GO:0005618 [cell wall] GO:0005975 [carbohydrate metabolic process] GO:0005993 [trehalose catabolic process] Show all	737 aa 80.7 kDa	No	0
ATHL1-008 ENSP00000380780 ENST00000397660	H3BM00 [Direct mapping] Acid trehalase-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0008152 [metabolic process] Show all	193 aa 20.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.