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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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IFNAR1
  • TISSUE

  • CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

IFNAR1

Gene description

Interferon (alpha, beta and omega) receptor 1

Protein class

Cancer-related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA018015 , HPA029226
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA018015
HPA029226

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were weakly stained or negative. A majority of pancreatic cancers as well as several liver, renal and lung cancers showed moderate cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Papillary adenocarcinomas of thyroid, pancreatic and several stomach cancers along with few gliomas, adenocarcinomas of lung, testicular, liver and urothelial cancers displayed moderate cytoplasmic and occasional membranous immunoreactivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

IFNAR1 (HGNC Symbol)

Synonyms

IFNAR, IFRC

Description

Interferon (alpha, beta and omega) receptor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.11

Chromosome location (bp)

33324477 - 33359862

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142166 (version 83.38)

Entrez gene

3454

UniProt

P17181 (UniProt - Evidence at protein level)

neXtProt

NX_P17181

Antibodypedia

IFNAR1 antibodies

PROTEIN BROWSER

IFNAR1-001
IFNAR1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IFNAR1-001
ENSP00000270139
ENST00000270139
P17181 [Direct mapping]
Interferon alpha/beta receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004904 [interferon receptor activity]
GO:0004905 [type I interferon receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0042110 [T cell activation]
GO:0045351 [type I interferon biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
Show all
557 aa
63.5 kDa
Yes 1
IFNAR1-003
ENSP00000400161
ENST00000442071
C9J114 [Direct mapping]
Interferon alpha/beta receptor 1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
136 aa
15.4 kDa
Yes 0

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