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DNMT3L

GENERAL INFORMATION

Gene name

 DNMT3L

Gene description

 DNA (cytosine-5-)-methyltransferase 3-like

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enriched (BEWO)
HPA (normal tissue):Group enriched (kidney, liver, lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA066780
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA066780

GENE INFORMATION

Gene name

 DNMT3L (HGNC Symbol)

Synonyms

 MGC1090

Description

 DNA (cytosine-5-)-methyltransferase 3-like (HGNC Symbol)

Entrez gene summary

 CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44246339 - 44262216

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142182 (version 83.38)

Entrez gene

 29947

UniProt

 Q9UJW3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJW3

Antibodypedia

 DNMT3L antibodies

PROTEIN BROWSER
DNMT3L-001
DNMT3L-002
DNMT3L-003
DNMT3L-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNMT3L-001
ENSP00000270172
ENST00000270172
Q9UJW3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3-like
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0007283 [spermatogenesis]
GO:0008047 [enzyme activator activity]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043085 [positive regulation of catalytic activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 387 aa
43.7 kDa 		No 0
DNMT3L-002
ENSP00000400242
ENST00000431166
C9J0T5 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3-like
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Predicted intracellular proteins
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 288 aa
32.4 kDa 		No 0
DNMT3L-003
ENSP00000411608
ENST00000436357
H7C3F7 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3-like
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Predicted intracellular proteins
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 181 aa
20.4 kDa 		No 0
DNMT3L-004
ENSP00000486001
ENST00000628202
Q9UJW3 [Direct mapping]
DNA (cytosine-5)-methyltransferase 3-like
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0007283 [spermatogenesis]
GO:0008047 [enzyme activator activity]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043085 [positive regulation of catalytic activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 386 aa
43.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.