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TRPM2

GENERAL INFORMATION

Gene name

 TRPM2

Gene description

 Transient receptor potential cation channel, subfamily M, member 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in selected tissues, most abundant in subsets of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035260
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 TRPM2 (HGNC Symbol)

Synonyms

 EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7

Description

 Transient receptor potential cation channel, subfamily M, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44350163 - 44443081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142185 (version 83.38)

Entrez gene

 7226

UniProt

 O94759 (UniProt - Evidence at protein level)

neXtProt

 NX_O94759

Antibodypedia

 TRPM2 antibodies

PROTEIN BROWSER
TRPM2-001
TRPM2-002
TRPM2-004
TRPM2-006
TRPM2-007
TRPM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPM2-001
ENSP00000381023
ENST00000397928
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0032024 [positive regulation of insulin secretion]
GO:0033194 [response to hydroperoxide]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044849 [estrous cycle]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
GO:0098703 [calcium ion import across plasma membrane]
GO:1903223 [positive regulation of oxidative stress-induced neuron death]
Show all
 1503 aa
171.2 kDa 		No 7
TRPM2-002
ENSP00000300481
ENST00000300481
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1449 aa
165.3 kDa 		No 7
TRPM2-004
ENSP00000300482
ENST00000300482
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1503 aa
171.2 kDa 		No 7
TRPM2-006
ENSP00000393982
ENST00000431901
C9JZQ8 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted intracellular proteins
Show all
GO:0005261 [cation channel activity]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0098655 [cation transmembrane transport]
Show all
 144 aa
16.4 kDa 		No 0
TRPM2-007
ENSP00000381026
ENST00000397932
E9PGK7 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0006811 [ion transport]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 1553 aa
176.5 kDa 		No 7
TRPM2-201
ENSP00000477514
ENST00000621064
A0A087WT16 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted intracellular proteins
Show all
GO:0005261 [cation channel activity]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0098655 [cation transmembrane transport]
Show all
 247 aa
28.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.