Expression of URB1 in cancer - Summary - The Human Protein Atlas

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URB1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	URB1
Gene description	URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and nucleolar expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA018334
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018334

GENE INFORMATION
Gene name	URB1 (HGNC Symbol)
Synonyms	C21orf108, KIAA0539, NPA1
Description	URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	32311018 - 32393026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142207 (version 83.38)
Entrez gene	9875
UniProt	O60287 (UniProt - Evidence at protein level)
neXtProt	NX_O60287
Antibodypedia	URB1 antibodies

PROTEIN BROWSER

URB1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
URB1-001 ENSP00000372199 ENST00000382751	O60287 [Direct mapping] Nucleolar pre-ribosomal-associated protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005730 [nucleolus] GO:0008150 [biological_process] GO:0044822 [poly(A) RNA binding] Show all	2271 aa 254.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.