Fields »
ABOUT
HELP
BLOG
IL19

GENERAL INFORMATION

Gene name

 IL19

Gene description

 Interleukin 19

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Cell line enriched (BJ hTERT+)
HPA (normal tissue):Tissue enriched (cervix, uterine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 IL19 (HGNC Symbol)

Synonyms

 IL-10C, IL-19, MDA1, NG.1, ZMDA1

Description

 Interleukin 19 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206798870 - 206842981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142224 (version 83.38)

Entrez gene

 29949

UniProt

 Q9UHD0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHD0

Antibodypedia

 IL19 antibodies

PROTEIN BROWSER
IL19-001
IL19-002
IL19-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL19-001
ENSP00000343000
ENST00000340758
Q9UHD0 [Direct mapping]
Interleukin-19
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0042226 [interleukin-6 biosynthetic process]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0072593 [reactive oxygen species metabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 215 aa
24.6 kDa 		No 1
IL19-002
ENSP00000270218
ENST00000270218
Q9UHD0 [Direct mapping]
Interleukin-19
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0046427 [positive regulation of JAK-STAT cascade]
Show all
 177 aa
20.5 kDa 		Yes 0
IL19-201
ENSP00000482668
ENST00000620365
Q9UHD0 [Direct mapping]
Interleukin-19
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0046427 [positive regulation of JAK-STAT cascade]
Show all
 177 aa
20.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.