Cell atlas - EMP3 - The Human Protein Atlas

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EMP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EMP3
Gene description	Epithelial membrane protein 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051163
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051163	A549	Nuclear bodies
	HPA051163	U-2 OS	Nuclear bodies
	HPA051163	U-251 MG	Nuclear bodies

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000040212 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051163	NIH 3T3	No staining

GENE INFORMATION
Gene name	EMP3 (HGNC Symbol)
Synonyms	YMP
Description	Epithelial membrane protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48321509 - 48330553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142227 (version 83.38)
Entrez gene	2014
UniProt	P54852 (UniProt - Evidence at protein level)
neXtProt	NX_P54852
Antibodypedia	EMP3 antibodies

PROTEIN BROWSER

EMP3-001	EMP3-002	EMP3-003	EMP3-004	EMP3-006	EMP3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMP3-001 ENSP00000270221 ENST00000270221	P54852 [Direct mapping] Epithelial membrane protein 3 A0A024QZF8 [Target identity:100%; Query identity:100%] Epithelial membrane protein 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008219 [cell death] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0032060 [bleb assembly] Show all	163 aa 18.4 kDa	No	3
EMP3-002 ENSP00000470331 ENST00000599704	M0QZ66 [Direct mapping] Epithelial membrane protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016049 [cell growth] Show all	90 aa 10.4 kDa	No	1
EMP3-003 ENSP00000469341 ENST00000596315	M0QXS0 [Direct mapping] Epithelial membrane protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016049 [cell growth] Show all	94 aa 10.6 kDa	No	2
EMP3-004 ENSP00000471964 ENST00000594198	M0R1L9 [Direct mapping] Epithelial membrane protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016049 [cell growth] Show all	57 aa 6.4 kDa	No	1
EMP3-006 ENSP00000469194 ENST00000597279	P54852 [Direct mapping] Epithelial membrane protein 3 A0A024QZF8 [Target identity:100%; Query identity:100%] Epithelial membrane protein 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008219 [cell death] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0032060 [bleb assembly] Show all	163 aa 18.4 kDa	No	3
EMP3-007 ENSP00000469275 ENST00000593437	M0QXN1 [Direct mapping] Epithelial membrane protein 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.