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GEMIN7

GENERAL INFORMATION

Gene name

 GEMIN7

Gene description

 Gem (nuclear organelle) associated protein 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GEMIN7 (HGNC Symbol)

Synonyms

 FLJ13956

Description

 Gem (nuclear organelle) associated protein 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear ""gems"" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45079195 - 45091524

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142252 (version 83.38)

Entrez gene

 79760

UniProt

 Q9H840 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H840

Antibodypedia

 GEMIN7 antibodies

PROTEIN BROWSER
GEMIN7-001
GEMIN7-002
GEMIN7-003
GEMIN7-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEMIN7-001
ENSP00000270257
ENST00000270257
Q9H840 [Direct mapping]
Gem-associated protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016604 [nuclear body]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 131 aa
14.5 kDa 		No 0
GEMIN7-002
ENSP00000466342
ENST00000591607
Q9H840 [Direct mapping]
Gem-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016604 [nuclear body]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 131 aa
14.5 kDa 		No 0
GEMIN7-003
ENSP00000465704
ENST00000591747
Q9H840 [Direct mapping]
Gem-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016604 [nuclear body]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 131 aa
14.5 kDa 		No 0
GEMIN7-005
ENSP00000375813
ENST00000391951
Q9H840 [Direct mapping]
Gem-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016604 [nuclear body]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 131 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.