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CBLC

GENERAL INFORMATION

Gene name

 CBLC

Gene description

 Cbl proto-oncogene C, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, RT4)
HPA (normal tissue):Tissue enhanced (duodenum, skin, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues, including gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB008087
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB008087

GENE INFORMATION

Gene name

 CBLC (HGNC Symbol)

Synonyms

 CBL-3, CBL-SL, RNF57

Description

 Cbl proto-oncogene C, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 44777869 - 44800634

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142273 (version 83.38)

Entrez gene

 23624

UniProt

 Q9ULV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULV8

Antibodypedia

 CBLC antibodies

PROTEIN BROWSER
CBLC-001
CBLC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBLC-001
ENSP00000270279
ENST00000270279
Q9ULV8 [Direct mapping]
E3 ubiquitin-protein ligase CBL-C
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
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GO:0001784 [phosphotyrosine binding]
GO:0004871 [signal transducer activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017124 [SH3 domain binding]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
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 474 aa
52.5 kDa 		No 0
CBLC-002
ENSP00000340250
ENST00000341505
Q9ULV8 [Direct mapping]
E3 ubiquitin-protein ligase CBL-C
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004871 [signal transducer activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017124 [SH3 domain binding]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
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 428 aa
47.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.