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Estimation of protein expression could not be performed. View primary data.
ANTIBODY IHC RELIABILITY
Data reliability description
RNA-based expert annotation gave inconclusive results. Pending retesting on additional tissue. No internal RNA expression data available for correlation.
Among tumors, hepatocellular cancers, some adenocarcinomas and non-Hodgkins lymphomas and a small fraction of squamous cell cancers displayed strong cytoplasmic immunoreactivity. Other malignancies were generally moderately stained.
Tumor tissues exhibited weak to moderate cytoplasmic positivity. Renal cell carcinomas showed strong nuclear and cytoplasmic positivity. Some malignant carcinoids also displayed strong cytoplasmic staining. Squamous cell carcinomas, stomach and liver cancers were mainly weakly stained or negative.
GENE INFORMATION
Gene name
SLC6A3 (HGNC Symbol)
Synonyms
DAT, DAT1
Description
Solute carrier family 6 (neurotransmitter transporter), member 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]