Expression of RNPEPL1 in cancer - Summary - The Human Protein Atlas

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RNPEPL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNPEPL1
Gene description	Arginyl aminopeptidase (aminopeptidase B)-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036772
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036772

GENE INFORMATION
Gene name	RNPEPL1
Synonyms
Description	Arginyl aminopeptidase (aminopeptidase B)-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	240565804 - 240581372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142327 (version 83.38)
Entrez gene
UniProt	Q9HAU8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HAU8
Antibodypedia	RNPEPL1 antibodies

PROTEIN BROWSER

RNPEPL1-001	RNPEPL1-004	RNPEPL1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNPEPL1-001 ENSP00000270357 ENST00000270357	Q9HAU8 [Direct mapping] Arginyl aminopeptidase-like 1 Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	494 aa 55.5 kDa	No	0
RNPEPL1-004 ENSP00000403319 ENST00000437406	H7C200 [Direct mapping] Arginyl aminopeptidase-like 1 Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0019370 [leukotriene biosynthetic process] Show all	247 aa 27.5 kDa	No	0
RNPEPL1-005 ENSP00000414661 ENST00000451363	C9JSI2 [Direct mapping] Arginyl aminopeptidase-like 1 Show all	Predicted intracellular proteins Show all	GO:0006508 [proteolysis] Show all	114 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.