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CACNG8

GENERAL INFORMATION

Gene name

 CACNG8

Gene description

 Calcium channel, voltage-dependent, gamma subunit 8

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (AF22, HMC-1, TIME)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA041351
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA041351

GENE INFORMATION

Gene name

 CACNG8

Synonyms

Description

 Calcium channel, voltage-dependent, gamma subunit 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 53963040 - 53990215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142408 (version 83.38)

Entrez gene

 59283

UniProt

 Q8WXS5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8WXS5

Antibodypedia

 CACNG8 antibodies

PROTEIN BROWSER
CACNG8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNG8-001
ENSP00000270458
ENST00000270458
Q8WXS5 [Direct mapping]
Voltage-dependent calcium channel gamma-8 subunit
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0016247 [channel regulator activity]
GO:0019226 [transmission of nerve impulse]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0045211 [postsynaptic membrane]
GO:0070588 [calcium ion transmembrane transport]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
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 425 aa
43.3 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.