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Occasional cases of malignant lymphomas, stomach, pancreas, cervical and ovarian cancers displayed moderate cytoplasmic staining with additional membranous positivity in several cases. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
FBN3
Synonyms
Description
Fibrillin 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that belongs to the fibrillin gene family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. While several transcript variants may exist for this gene, their full-length natures have not been described to date. [provided by RefSeq, Jul 2008]