Cell atlas - TM4SF5 - The Human Protein Atlas

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TM4SF5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TM4SF5
Gene description	Transmembrane 4 L six family member 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cell junctions. In addition localized to the nucleoplasm.
RNA cell category	Group enriched (Hep G2, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain), Cell Junctions (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA055674
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cell junctions. In addition localized to the nucleoplasm.

Main location

Plasma membrane (uncertain), Cell Junctions (uncertain)

Additional location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055674	CACO-2	Nucleoplasm
	HPA055674	CACO-2	Cell Junctions
	HPA055674	Hep G2	Nucleoplasm
	HPA055674	Hep G2	Cell Junctions
	HPA055674	U-2 OS	Plasma membrane
	HPA055674	U-2 OS	Cell Junctions

GENE INFORMATION
Gene name	TM4SF5
Synonyms
Description	Transmembrane 4 L six family member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4771884 - 4783213
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142484 (version 83.38)
Entrez gene	9032
UniProt	O14894 (UniProt - Evidence at transcript level)
neXtProt	NX_O14894
Antibodypedia	TM4SF5 antibodies

PROTEIN BROWSER

TM4SF5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM4SF5-001 ENSP00000270560 ENST00000270560	O14894 [Direct mapping] Transmembrane 4 L6 family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0016021 [integral component of membrane] Show all	197 aa 20.8 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.