Expression of SLC47A1 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC47A1
Gene description	Solute carrier family 47 (multidrug and toxin extrusion), member 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (A549, Hep G2, U-266/70)
HPA (normal tissue):	Tissue enhanced (adrenal gland, kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in several tissues, most abundant in adrenal gland and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA021987
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (favourable) and lung cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA021987

GENE INFORMATION
Gene name	SLC47A1 (HGNC Symbol)
Synonyms	FLJ10847, MATE1
Description	Solute carrier family 47 (multidrug and toxin extrusion), member 1 (HGNC Symbol)
Entrez gene summary	This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19495385 - 19579034
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142494 (version 83.38)
Entrez gene	55244
UniProt	Q96FL8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FL8
Antibodypedia	SLC47A1 antibodies

PROTEIN BROWSER

SLC47A1-001	SLC47A1-002	SLC47A1-005	SLC47A1-006	SLC47A1-007	SLC47A1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC47A1-001 ENSP00000270570 ENST00000270570	Q96FL8 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005451 [monovalent cation:proton antiporter activity] GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015695 [organic cation transport] GO:0015893 [drug transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031988 [membrane-bounded vesicle] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	570 aa 61.9 kDa	No	>9
SLC47A1-002 ENSP00000378951 ENST00000395585	Q96FL8 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005451 [monovalent cation:proton antiporter activity] GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015695 [organic cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031988 [membrane-bounded vesicle] GO:0055085 [transmembrane transport] Show all	586 aa 63.5 kDa	No	>9
SLC47A1-005 ENSP00000462630 ENST00000571335	J3KSS8 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	316 aa 34.3 kDa	No	6
SLC47A1-006 ENSP00000407155 ENST00000436810	E7EX57 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	443 aa 48 kDa	No	>9
SLC47A1-007 ENSP00000460164 ENST00000575023	I3L345 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	268 aa 29.3 kDa	No	4
SLC47A1-014 ENSP00000462225 ENST00000581558	J3KRZ3 [Direct mapping] Multidrug and toxin extrusion protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	99 aa 10.8 kDa	No	1