Fields »
ABOUT
HELP
BLOG
NOSIP

GENERAL INFORMATION

Gene name

 NOSIP

Gene description

 Nitric oxide synthase interacting protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043464
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA043464

GENE INFORMATION

Gene name

 NOSIP (HGNC Symbol)

Synonyms

 CGI-25

Description

 Nitric oxide synthase interacting protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49555711 - 49590262

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142546 (version 83.38)

Entrez gene

 51070

UniProt

 Q9Y314 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y314

Antibodypedia

 NOSIP antibodies

PROTEIN BROWSER
NOSIP-001
NOSIP-004
NOSIP-005
NOSIP-008
NOSIP-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOSIP-001
ENSP00000470034
ENST00000596358
Q9Y314 [Direct mapping]
Nitric oxide synthase-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0043086 [negative regulation of catalytic activity]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
Show all
 301 aa
33.2 kDa 		No 0
NOSIP-004
ENSP00000473109
ENST00000599537
M0R3B2 [Direct mapping]
Nitric oxide synthase-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 242 aa
26.9 kDa 		No 0
NOSIP-005
ENSP00000468974
ENST00000598544
M0QX85 [Direct mapping]
Nitric oxide synthase-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0016567 [protein ubiquitination]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 96 aa
11.1 kDa 		No 0
NOSIP-008
ENSP00000343497
ENST00000339093
A0A075B6F9 [Direct mapping]
Nitric oxide synthase-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 304 aa
33.4 kDa 		No 0
NOSIP-010
ENSP00000471929
ENST00000598296
M0R1K2 [Direct mapping]
Nitric oxide synthase-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 176 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.