Expression of SLC2A5 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC2A5
Gene description	Solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, renal cancer)
HPA (cell line):	Cell line enhanced (Daudi, U-266/70, U-698, U-937)
HPA (normal tissue):	Tissue enhanced (duodenum, small intestine, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in microvilli in cells of gastrointestinal tract and kidney, cell membranes in seminiferous ducts in testis and cytoplasm in a subset of glial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA005449
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005449

GENE INFORMATION
Gene name	SLC2A5 (HGNC Symbol)
Synonyms	GLUT5
Description	Solute carrier family 2 (facilitated glucose/fructose transporter), member 5 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.23
Chromosome location (bp)	9035107 - 9088478
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142583 (version 83.38)
Entrez gene	6518
UniProt	P22732 (UniProt - Evidence at protein level)
neXtProt	NX_P22732
Antibodypedia	SLC2A5 antibodies

PROTEIN BROWSER

SLC2A5-001	SLC2A5-002	SLC2A5-005	SLC2A5-006	SLC2A5-007	SLC2A5-008	SLC2A5-009	SLC2A5-010	SLC2A5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A5-001 ENSP00000366641 ENST00000377424	P22732 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0008645 [hexose transport] GO:0015755 [fructose transport] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071332 [cellular response to fructose stimulus] GO:1904659 [glucose transmembrane transport] Show all	501 aa 55 kDa	No	>9
SLC2A5-002 ENSP00000366631 ENST00000377414	P22732 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0008645 [hexose transport] GO:0015755 [fructose transport] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071332 [cellular response to fructose stimulus] GO:1904659 [glucose transmembrane transport] Show all	244 aa 26.5 kDa	No	5
SLC2A5-005 ENSP00000465285 ENST00000473209	K7EJR1 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	81 aa 9.1 kDa	Yes	0
SLC2A5-006 ENSP00000464880 ENST00000474145	K7EIT1 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	190 aa 20.6 kDa	No	5
SLC2A5-007 ENSP00000467039 ENST00000484798	K7EIT1 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	190 aa 20.6 kDa	No	5
SLC2A5-008 ENSP00000468590 ENST00000479813	K7EIT1 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	190 aa 20.6 kDa	No	5
SLC2A5-009 ENSP00000465507 ENST00000486632	K7EIT1 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	190 aa 20.6 kDa	No	5
SLC2A5-010 ENSP00000467840 ENST00000464985	K7EQI3 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	139 aa 15.2 kDa	No	2
SLC2A5-011 ENSP00000465382 ENST00000487835	K7EJZ0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005353 [fructose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015755 [fructose transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	166 aa 18 kDa	No	4