Tissue expression of PRDM16 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRDM16
Gene description	PR domain containing 16
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (thyroid gland)
FANTOM5:	Tissue enhanced (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION
Gene name	PRDM16 (HGNC Symbol)
Synonyms	KIAA1675, MEL1, MGC166915, PFM13
Description	PR domain containing 16 (HGNC Symbol)
Entrez gene summary	The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	3069168 - 3438621
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142611 (version 83.38)
Entrez gene	63976
UniProt	Q9HAZ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAZ2
Antibodypedia	PRDM16 antibodies

PROTEIN BROWSER

PRDM16-001	PRDM16-002	PRDM16-003	PRDM16-004	PRDM16-007	PRDM16-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM16-001 ENSP00000270722 ENST00000270722	Q9HAZ2 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0017053 [transcriptional repressor complex] GO:0019827 [stem cell population maintenance] GO:0022008 [neurogenesis] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030853 [negative regulation of granulocyte differentiation] GO:0033613 [activating transcription factor binding] GO:0035019 [somatic stem cell population maintenance] GO:0043457 [regulation of cellular respiration] GO:0043565 [sequence-specific DNA binding] GO:0043586 [tongue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding] GO:0050872 [white fat cell differentiation] GO:0050873 [brown fat cell differentiation] GO:0060021 [palate development] GO:0090336 [positive regulation of brown fat cell differentiation] Show all	1276 aa 140.3 kDa	No	0
PRDM16-002 ENSP00000425796 ENST00000509860	H0YA13 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1084 aa 119.4 kDa	No	0
PRDM16-003 ENSP00000367643 ENST00000378391	Q9HAZ2 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0017053 [transcriptional repressor complex] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030853 [negative regulation of granulocyte differentiation] GO:0033613 [activating transcription factor binding] GO:0043457 [regulation of cellular respiration] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0050873 [brown fat cell differentiation] Show all	1257 aa 138.2 kDa	No	0
PRDM16-004 ENSP00000476002 ENST00000463591	U3KQL6 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	53 aa 5.9 kDa	No	0
PRDM16-007 ENSP00000426975 ENST00000511072	D6RDW0 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1178 aa 129.8 kDa	No	0
PRDM16-008 ENSP00000421400 ENST00000514189	D6RFY3 [Direct mapping] PR domain zinc finger protein 16 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1177 aa 129.7 kDa	No	0