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Gene name

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Subclass

Chromosome

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In atlas

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CELA2A
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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

CELA2A

Gene description

Chymotrypsin-like elastase family, member 2A

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

CELA2A (HGNC Symbol)

Synonyms

ELA2A

Description

Chymotrypsin-like elastase family, member 2A (HGNC Symbol)

Entrez gene summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

Chromosome

1

Cytoband

p36.21

Chromosome location (bp)

15456728 - 15472091

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142615 (version 83.38)

Entrez gene

63036

UniProt

P08217 (UniProt - Evidence at protein level)

neXtProt

NX_P08217

Antibodypedia

CELA2A antibodies

PROTEIN BROWSER

CELA2A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CELA2A-001
ENSP00000352639
ENST00000359621
P08217 [Direct mapping]
Chymotrypsin-like elastase family member 2A
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0017171 [serine hydrolase activity]
GO:0036457 [keratohyalin granule]
Show all
269 aa
28.9 kDa
Yes 0

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