Expression of PADI1 in cancer - Summary - The Human Protein Atlas

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PADI1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PADI1
Gene description	Peptidyl arginine deiminase, type I
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (pancreatic cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, EFO-21, HaCaT, LHCN-M2, RPTEC TERT1)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in esophagus.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA062294
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA062294

GENE INFORMATION
Gene name	PADI1 (HGNC Symbol)
Synonyms	HPAD10, PAD1, PDI, PDI1
Description	Peptidyl arginine deiminase, type I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	17205126 - 17246005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142623 (version 83.38)
Entrez gene	29943
UniProt	Q9ULC6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9ULC6
Antibodypedia	PADI1 antibodies

PROTEIN BROWSER

PADI1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PADI1-001 ENSP00000364620 ENST00000375471	Q9ULC6 [Direct mapping] Protein-arginine deiminase type-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004668 [protein-arginine deiminase activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0018101 [protein citrullination] GO:0070062 [extracellular exosome] Show all	663 aa 74.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.