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Cancer tissues showed moderate to strong cytoplasmic staining in a granular pattern.
GENE INFORMATION
Gene name
PEX14
Synonyms
Description
Peroxisomal biogenesis factor 14 (HGNC Symbol)
Entrez gene summary
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]